Database of our projects

Since 1998 until 2007 we promoted 25 projects, whose details including abstracts and some final reports you will find under the following Links.

Project 32 advanced scholarship 2
- Abnormalities of lipid droplet biogenesis: a novel pathogenic twist in hereditary spastic paraplegia
Project 31
- Paris - Conference
Project 30
- Unraveling the molecular basis of hereditary spastic paraplegias –
Project 29
- Analysis of the cellular functions of the Dictyostelium strumpellin ortholog.
- Researcher group
Project 28
- Identification of mutated genes in novel forms of HSP
- Final report
- the research group
advanced scholarship
- Our anniversary project 2009
Project 26
- Characterising a novel form of complicated hereditary spastic paraplegia
- Final report
Project 25
- Treadmill-training in Hereditary Spastic Paraplegia: Effects on Cortico-Spinal Reflex-modulation, Walking und Quality of Life
Project 24
- Intracellular Sort- and Transportsystems in HSP - in vitro and in vivo models for testing the role of Atlastin and KIF5A
Project 23
- Final report
- Generation of a mouse model for Zfyve27, the gene which is mutated in hereditary spastic paraplegia (SPG33)
Project 22
- The Molecular Pathology of NIPA1-associated Hereditary Spastic Paraplegia
Project 21
- Candidate gene- analysis at complicated HSP with thin Corpus Callosum (SPG11)
Project 21A
- How to charcterize spezific interaktion partner of Atlastin1
Project 20
- Screening for disease-associated copy number aberrations in autosomal dominant hereditary spastic paraplegia using multiplex ligation-dependent probe amplification (MLPA)
Project 19
- Efficacy and safety of levodopa treatment in patients with hereditary spastic paraplegia (HSP)
Project 18
- Final report
- Refinement of the SPG5 locus and identification of candidate genes and mutations in SPG5- and SPG30-positive families
Project 17
- Towards a cellular and molecular understanding of hereditary spastic paraplegia:
Project 16
- Nipa1 function and mouse models for hereditary spastic paraplegia
Project 15
- Comparison of Physiotherapy Methods Using Hereditary Spastic Spinal Paralysis (HSP) as Example
Project 14
- Investigations of the familial and social situation, coping strategies and opinions of people, suffering from hereditary spastic paraplegia and of their relatives to genetic diagnosis
Project 13
- Checking patients with simple an complicated HSP by DTI to find subtyping of the heterogeneous group of disease
- final reports
Project 12
- The FSP- research team at Jena under leadership from Prof. Deufel operates at present a project for functional characterization of spastin.
Project 11
- Screening for disease-associated copy number aberrations in autosomal dominant hereditary spastic paraplegia using multiplex ligation-dependent probe amplification
Project 10
- Troyer Syndrom (SPG 20 ) genetic and functional analysis of a microtubli-associated disease
- Final reporting
Project 9
- Nipa1 function and mouse models for hereditary spastic paraplegia
Project 8
- Construction of a SPG1- and SPG4- Tetanus-Toxin-Hybridprotein for the intraneuronal transport of the L1-CAM and Spastin-Protein – model of a new therapy method?
Project 7
- Reconstitution of neural functions in the spinal cord through neural stem cells expressing the neural cell adhesion molecule L1
Project 6
- Clinical trial of medical condition in combination with HSP including the physiotherapeutical treatment
Project 5
- Indentifying gene of silver syndrome by verification of mutations
Project 4
- Hereditary spastic paraparesis with amyotrophy of the hands (Silver syndrome): Cellular expression analysis of the mutated Silver gene
Project 3
- Isolation of peptides binding to the neural cell adhesion molecule L1 that enhance neurite outgrowth and neuronal survival
- Final report
Project 3a
- mutation analysis on families with HSP and some without family history
- Applicant Dr. Alba
- final report
Project2
- Clinical and molecular-genetic characterization of patients
Project 1
- Evaluation of treatment of HSP with Ritalin
- Final report given at the TWS Symposium Nr. 2 at Kassel 2002