Symposium 2018

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17. TWS-Symposium am 16. März 2018 im Rahmen des DGKN-Kongresses an der Freien Universität Berlin 

Hereditary Spastic Paraplegias and related disorders: Update on research concepts and on therapeutic strategies

 

Time Speaker (in alphabetical order) Title
9:00

Tom Wahlig

Rebecca Schüle

Welcome and introduction

9:10Matthis Synofzik (Universitätsklinikum Tübingen, GER)Overcoming the divide between ataxias and spastic paraplegias: Shared phenotypes, genes and pathways
9:30Bernard Brais (University of Montréal, CAN) The molecular pathophysiology of ARSACS: when the cytoskeleton bundles
9:50Hélène Puccio (Illkirch, Institut de Génétique et de Biologie moléculaire et cellulaire, F)Mitochondrial recessive ataxias - from models to gene therapy approaches
10:10: Coffee break
10:30Rebecca Schüle Novel TWS funding project: Introduction in awardees
10:45Martin Regensburger (Friedrich-Alexander-Universität Erlangen, GER)Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia
11:00Rachel Allison (Cambridge Institute for Medical Researchs, U.K.)Investigating a novel phenotype of lyosomal dysfunction in spartin-HSP
11:15Molly Lettman (University of Wisconsin-Madison, USA)Therapeutic strategies to treating hereditary spastic paraplegias
11:30Hamid Azzedine (Universitätsklinikum RWTH AAchen, GER)

Preliminary data from NGS in consanguineous families with Spastic Paraplegia and related neuropathies

 

11:50

Evan Reid (Cambridge Institute for Medical Research, UK)

Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia

12:10Giovanni Stevanin (Institut du Cerveau et de Moelle épinière, Paris, F)  CYP2U1 Knock-out partially mimics the spastic paraplegia 56 phenotype
12:30: Lunch break
13:45: guided poster session, Henry-Ford-building, Garystr. 35
15:00Markus Damme (Universität Kiel, GER) Aberrant axonal transport of Lyosomes in Disease
15:30Cahir O´Kane (University of Cambridge, U.K.) Architecture and continuity of axonal endoplasmic reticulum are compromised on loss of intramembrane hairpin-containing HSP proteins in Drosophila
16:00: Coffee break
16:30Julian Großkreutz (Universitätsklinikum Jena, GER) Progression of ALS: The clinical syndrome and the biomarker profile
17:00Rebecca Schüle (Universitätsklinikum Tübingen, GER) An HSP biomarker initiative
18:15: by bus to hotel (restaurant close by)
19:30: Awarding of poster prices and dinner