20th TWS symposium on November 26th in Essen
Live: on site and in the stream

We are cautiously optimistic and hope to be able to hold our 20th symposium on November 26th, 2021 at the University Hospital Essen as a face-to-face event. Prof. Stephan Klebe and Prof. Christel Depienne (both UK Essen) designed an exciting program and invited many interesting speakers from all over the world to speak about clinical studies, treatment options and basic research on HSP.

The whole event will also be offered as a live stream again at www.hsp-info.de.

On the evening before (November 25th, 2021) we would like to invite you to our "traditional" dinner and hope that it will be possible to be together and to exchange ideas over dinner! It will take place at the restaurant "Villa Vue", Weg zur Platte73, 45239 Essen.

We cordially invite all participants to dinner. We also cover travel and accommodation costs for the speakers.

We have reserved room allotments in the following hotels:

50 rooms: Welcome Hotel, Schützenbahn 58, 45127 Essen (single room including breakfast: 103, - €)

10 rooms: Mintrops Stadt Hotel Margarethenhöhe, Steile Straße 46, 45149 Essen (single room including breakfast: € 99)

Registration and reservations are made through the Tom Wahlig Foundation.

The program of the 20th symposium:

Time Speaker Title
8:50 Tom Wahlig + Stephan Klebe Opening
9:00 Kishore Raj Kumar (Syndney, AUS) Challenges and Controversies in the Genetic Diagnosis of HSP
9:30 Fanny Mochel (Paris, FRA) Update on complex lipids in HSP
10:00 Nathalie De Beukelaer (Leuven, BEL) Muscle Characteristics in Pediatric HSP vs. Bilateral Spastic Cerebral Palsy: An Exploartory Study
10:30 Coffee Break  
10:50 Andrea Martinuzzi/Marinela Vavla (Lecco, ITA) Brain Magnetic Spectroscopy Imaging and HSP
11:20 Rebecca Schüle/Matthis Synofzik (Tübingen, GER) PROSPAX
11:50 Ludger Schöls (Tübingen, GER) 2021 TWS funding round: Introduction
12:00 Catherine Rodger (Cambridge, GB) Development of AAV-mediated gene therapy for hereditary spastic paraplegia
12:10 Darius Ebrahimi-Fakhari (Boston, USA) Characterization of ap4b1-/- zebrafish as a novel in vivo model of SPG47 and its application in small molecule screens
12:20 Gerald Fischer (AUT) Adolf-Strumpell-Prize for HSP-Therapy: Introduction
12:30 N.N. title to come
12:40 Lunch Break  
13:45 Peter Baas (Philadelphia, USA) Mechanistic Route to Therapy for SPG4 Hereditary Spastic Paraplegia
14:15 Aurora Pujol (Barcelona, ESP) Novel metabolic genes causing HSP: the SHMT2 and PIA4KA cases
14:45 Stefan Hauser (Tübingen, GER) Comparative transcrisptional profiling of motor neuron disorder-associated genes in various human cell culture models
15:15 Coffee Break  
15:40 Ziv Gan-Or (Montreal, CAN) CanHSP: genetic and clinical lessons on HSP from a Canadian consortium
16:10 Darius Ebrahimi-Fakhari (Boston, USA) AP-4-associated Hereditary Spastic Paraplegia – A Translational Approach to An Ultra-rare Disease
16:40 Craig Blackstone (Boston, USA) New Insights into ER Morphology Dysregulation in Hereditary Spastic Paraplegias
17:10   Concluding remarks