TWS Symposium 2022
1./2. December 2022 in Tübingen
TWS Symposium I treatHSP Meeting 2022
| Thursday, Dec. 1 | |||
Session 1: HSP around the world | Speaker | Title | |
Chair: Rebecca Schüle
| 9:15 | Hiroyuki Ishiura (Okayama) | Landscapes of HSP in Japan and Japan Spastic Paraplegia Research Consortium (JASPAC) |
| 9:45 | Jeannine M. Heckmann (Cape Town) | Landscapes of HSP in Africa | |
| 10:15 | Jonas Alex Morales Saute (Porto Alegre, Brazil) | Landscapes of HSP in South America | |
| 10.45 | Coffee Break | ||
Session 2: Diagnosing and studying the natural hiostory of HSPs | |||
| Chair: Rebecca Schüle | 11:00 | Caig Blackstone, Darius Ebrahimi-Fakhari, Rebecca Schüle, Stephan Züchner | Developement of Centers of Excellence to support a North American Registry and Natural History Study for HSP |
| 11:30 | Darius Ebrahimi-Fakhari (Boston) | The clinical and molecular spectrum of ZFYVE26-associated HSP (SPG15) | |
| 12:00 | Giovanni Stevanin (Paris) | Improving the diagnosis odyssey in hereditary Spastic Paraplegia | |
| 12:30 | Lunch and Poster Session | ||
Session 3: New SPG genes | |||
| Chair: Christel Depienne | 14:15 | Stefan Kindler (Hamburg) | Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia |
| 14:45 | Jonathan Baets (Antwerpen) | SPTAN1 mutations in spastic ataxia: new phenotypes expanding the neuro-spectrinopathies | |
| 15:15 | Daniel Calame (Houston) | Biallelic Variants in the Ectonucleotidase ENTPD1 Cause a Complex Neurodevelopmental Disorder with Intellectual Disability, Distinct White Matter Abnormalities, and Spastic Paraplegia | |
| 15:45 | Coffee Break | ||
Session 4: New SPG genes,clinical overlap with other disorders,genetic modifiers | |||
Chair: Christel Depienne | 16:00 | Stephan Züchner (Miami) | Closing the diagnostic gap: new genes in HSP and related disorders |
| 16:30 | Livia Parodi (Paris, Harvard) | Genetic modifiers of SPG4-HSP | |
| 17:00 | Bart Van de Warrenburg (Nijmegen) | Recognizing and exploiting the overlap between hereditary spastic paraplegia and ataxias | |
| 19:00 | Get Together and Dinner at Liquid Kelter | ||
| Friday, Dec. 2 | |||
Session 5: Deciphering mechanisms causing HSPs using cellular and animal models | |||
Chair: Stephan Klebe | 9:00 | Stefan Hauser (Tübingen) | (iPSC-based) advanced cell culture models to decipher disease mechanisms in HSP |
| 9:30 | Beate Winner (Erlangen) | New mechanisms for motor neuron disease derived from human stem cell based models | |
| 10:00 | Christian Hübner (Jena) | Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation | |
| 10:30 | Coffee Break | ||
Session 6: Monitoring HSP progression in clinical studies
| |||
Chair: Stephan Klebe | 11:00 | Heiko Gaßner (Erlangen) | 5D gait analysis - perspectives for innovative digital precision medicine in HSP |
| 11:30 | Graziella Donatelli (Pisa) | Iron-sensitive MR imaging of the primary motor cortex in Hereditary Spastic Paraplegia | |
| 12:00 | Ludger Schöls (Tübingen) | Gait changes in Prodromal Hereditary Spastic Paraplegia Type 4 | |
| 12:00 | Lunch and Poster Session | ||
Session 7: Awards Ceremony | |||
| TWS Research Award | 13:30 | Julia Kleniuk (Cambridge) | Investigating the role of spastin‘s binding partner protrudin in endosomal sorting |
| TWS Research Award | 13:45 | Afshin Saffari (Boston) | Using Label-free Proteomics for Target Identification and Validation of Novel Treatments for AP-4-associated Hereditary Spastic Paraplegia |
| Adolf-Struempell-Prize | 14:00 | Martin Regensburger (Erlangen) | Measures of mobility and functioning in hereditary spastic paraplegia |
| Poster Prizes 3x | 14:15 | N.N. | Nomination of 3 poster prizes |
Session 8: Precision medicine approaches to treat HSP | |||
Chair: Ludger Schöls | 14:30 | Hande Ozdinler (Chicago) | Understanding the biology and pathology of upper motor neurons: one neuron at a time |
| 15:00 | Filippo Santorelli (Rom) | Testing Miglustat in SPG11: a single center experience | |
| 15:30 | Xin Chen (Dallas) | Development of an Intrathecal AAV9/AP4M1 Gene Therapy for Hereditary Spastic Paraplagia 50 | |
| 16:00 | End of the event |
This year, the project partners of the Tom Wahlig Foundation and treatHSP invite you to a joint meeting, which will take place in early December in Tübingen.
Even more than in the previous two years, this time we will bundle our topics and focal points of research work in order to jointly present the current state of HSP research. Renowned international experts will have a unique forum to exchange and discuss their research approaches, projects and results.
Numerous young scientists who have already come into contact with hereditary spastic paraplegia through their work and are interested in furthering their education and expanding their network in this field of research will present a poster.
A TWS poster prize of 300 € will be awarded to the three best posters.
The meeting will take place in the WESTSPITZE Tübingen, directly east of the Blaue Brücke (Eisenbahnstraße 1, 72072 Tübingen, access via Hanna-Bernheim-Strasse 2.
On the evening of December 1, we invite you to dine together at the Liquid Kelter restaurant (Schmiedtorstrasse 17, 72070 Tübingen).
Room allotments are no longer available. Who still wants to register, writes an e-mail to susanne.wahlig@hsp-info.de.