TWS Symposium 2022
1./2. December 2022 in Tübingen

TWS Symposium I treatHSP Meeting 2022

Thursday, Dec. 1      

Session 1:

HSP around the world

  Speaker Title

Chair: Rebecca Schüle


9:15 Hiroyuki Ishiura (Okayama) Landscapes of HSP in Japan and Japan Spastic Paraplegia Research Consortium (JASPAC)
9:45 Jeannine M. Heckmann (Cape Town) Landscapes of HSP in Africa
10:15 Jonas Alex Morales Saute (Porto Alegre, Brazil) Landscapes of HSP in South America
  10.45 Coffee Break  

Session 2:

Diagnosing and studying the natural hiostory of HSPs

Chair: Rebecca Schüle 11:00

Caig Blackstone, Darius Ebrahimi-Fakhari, Rebecca Schüle, Stephan Züchner

Developement of Centers of Excellence to support a North American Registry and Natural History Study for HSP
11:30 Darius Ebrahimi-Fakhari (Boston) The clinical and molecular spectrum of ZFYVE26-associated HSP (SPG15)
12:00 Giovanni Stevanin (Paris) Improving the diagnosis odyssey in hereditary Spastic Paraplegia
  12:30 Lunch and Poster Session  

Session 3:

New SPG genes

Chair: Christel Depienne 14:15 Stefan Kindler (Hamburg) Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia
14:45 Jonathan Baets (Antwerpen) SPTAN1 mutations in spastic ataxia: new phenotypes expanding the neuro-spectrinopathies
15:15 Daniel Calame (Houston) Biallelic Variants in the Ectonucleotidase ENTPD1 Cause a Complex Neurodevelopmental Disorder with Intellectual Disability, Distinct White Matter Abnormalities, and Spastic Paraplegia
  15:45 Coffee Break  

Session 4:

New SPG genes,clinical overlap with other disorders,genetic modifiers



Christel Depienne

16:00 Stephan Züchner (Miami) Closing the diagnostic gap: new genes in HSP and related disorders
16:30 Livia Parodi (Paris, Harvard) Genetic modifiers of SPG4-HSP
17:00 Bart Van de Warrenburg (Nijmegen) Recognizing and exploiting the overlap between hereditary spastic paraplegia and ataxias
  19:00 Get Together and Dinner at Liquid Kelter  
Friday, Dec. 2      

Session 5:

Deciphering mechanisms causing HSPs using cellular and animal models



Stephan Klebe

9:00 Stefan Hauser (Tübingen) (iPSC-based) advanced cell culture models to decipher disease mechanisms in HSP
9:30 Beate Winner (Erlangen) New mechanisms for motor neuron disease derived from human stem cell based models
10:00 Christian Hübner (Jena) Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation
  10:30 Coffee Break  

Session 6:

Monitoring HSP progression in clinical studies




Stephan Klebe

11:00 Heiko Gaßner (Erlangen) 5D gait analysis - perspectives for innovative digital precision medicine in HSP
11:30 Graziella Donatelli (Pisa) Iron-sensitive MR imaging of the primary motor cortex in Hereditary Spastic Paraplegia
12:00 Ludger Schöls (Tübingen) Gait changes in Prodromal Hereditary Spastic Paraplegia Type  4
  12:00 Lunch and Poster Session  

Session 7:

Awards Ceremony

TWS Research Award 13:30 Julia Kleniuk (Cambridge) Investigating the role of spastin‘s binding partner protrudin in endosomal sorting
TWS Research Award 13:45 Afshin Saffari (Boston) Using Label-free Proteomics for Target Identification and Validation of Novel Treatments for AP-4-associated Hereditary Spastic Paraplegia
Adolf-Struempell-Prize 14:00 Martin Regensburger (Erlangen) Measures of mobility and functioning in hereditary spastic paraplegia
Poster Prizes 3x 14:15 N.N. Nomination of 3 poster prizes

Session 8:

Precision medicine approaches to treat HSP



Ludger Schöls

14:30 Hande Ozdinler (Chicago) Understanding the biology and pathology of upper motor neurons: one neuron at a time
15:00 Filippo Santorelli (Rom) Testing Miglustat in SPG11: a single center experience
15:30 Xin Chen (Dallas) Development of an Intrathecal AAV9/AP4M1 Gene Therapy for Hereditary Spastic Paraplagia 50
  16:00 End of the event  


This year, the project partners of the Tom Wahlig Foundation and treatHSP invite you to a joint meeting, which will take place in early December in Tübingen.

Even more than in the previous two years, this time we will bundle our topics and focal points of research work in order to jointly present the current state of HSP research.  Renowned international experts will have a unique forum to exchange and discuss their research approaches, projects and results.

Numerous young scientists who have already come into contact with hereditary spastic paraplegia through their work and are interested in furthering their education and expanding their network in this field of research will present a poster.
A TWS poster prize of 300 € will be awarded to the three best posters.

The meeting will take place in the WESTSPITZE Tübingen, directly east of the Blaue Brücke (Eisenbahnstraße 1, 72072 Tübingen, access via Hanna-Bernheim-Strasse 2.

On the evening of December 1, we invite you to dine together at the Liquid Kelter restaurant (Schmiedtorstrasse 17, 72070 Tübingen).

Room allotments are no longer available. Who still wants to register, writes an e-mail to